Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.
نویسندگان
چکیده
Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-alpha expression and NO production with IC(50) values of 6.8 and 5.2 muM, respectively.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 19 شماره
صفحات -
تاریخ انتشار 2010